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Background: The aim of this study was to investigate the effect of anabolic steroids on kidneys in bodybuilders. A total of 30 men aged 18-24 years with a body mass index (BMI) >30 kg/m(2) were matched with 30 control men on average. The men were divided into four groups: control, 2.5-3.5% (n = 29), high performance group (n = 25), heavy-only group (n = 23) and anabolic steroids group (n = 22). The groups were further divided into four groups depending on how they were measured. The controls had standard kidney examinations and blood pressure tests without being on any drug. The high performance group had an average BMI of >30 kg/m(2) and underwent a routine screening of its renal function. The heavy-only group was in the lowest category of renal function, whereas the anabolic steroids group was one of the highest. The men were randomized in a double-blind manner and the subjects were not aware of the order of the groups. Each subject was given three 100 mg intramuscular injections of oral anabolic steroids (n = 27) or placebo over three consecutive days. All of the samples were taken at approximately the same time (the first samples were taken in the presence of the subjects after the injection). The objective of the study was to determine the effects of anabolic steroids on the renal system with emphasis on its relation to the amount of the steroids used. In particular a complete analysis of the effects of the different anabolic steroids on blood pressure and urine and urinary parameters. The study was carried out in accordance with the Declaration of Helsinki. Statistical analysis For comparisons between groups the means, standard deviations, 95% CIs and P values for all parameters were calculated. The statistical significance for all these parameters was determined by a one-way analysis of variance (ANOVA) with Student's t-test or the χ2-test.Results During the eight weeks period a total of 19 samples were taken. In all groups the amount consumed per person was the same and the duration of the period is comparable ( ). Table 1 Group a Group b Control high performance Heavy-only anabolic steroids anabolic peptides (n = 24) 1.25 ± 0.41 1.20 ± 0.44 1.10 ± 0.28 1.00 ± 0.37 Controls normal controls Low levels 1.22 ± 0.43 1.14 ± 0.46 1.07 ± 0.35 1.01 ± 0.28 Open the page in a new window Open in a separate window OpenSimilar articles: